Long-term testosterone supplementation in older men attenuates age-related decline in aerobic capacity
Researchers performed a double-blind, randomized, placebo-controlled, parallel-group trial (Testosterone’s Effects on Atherosclerosis Progression in Aging Men) to determine the impacts of testosterone supplementation on peak oxygen uptake (V?O2peak) during incremental cycle ergometry. Participants in the study were healthy men aged ≥ 60 years with total testosterone levels of 100 to 400 ng/dL or free testosterone levels < 50 pg/mL. As compared to men receiving placebo, the mean 3-year change in V?O2peak was significantly smaller in men treated with testosterone and was correlated with increases in hemoglobin. The difference in V?O2peak change between groups might show lessening of its expected age-related decline.