Theresa----Do you mean nylon and Spandex? Instead of latex? If you are sewing nylon/spandex, use a Janome purple tip needle and one of the stretch stitches---I have a different machine (Skyline7), so I don't know what stitches your machine has. I use one of the "lightning" stitches for seams and the triple zigzag for stitching elastic in, or finishing the waist or leg openings in swimwear, or topstitching armholes and neckline. Nothing works as well as the Janome purple tip for me I believe Organ makes the Janome-branded needles. I have purchased the Purple Tip needles on Amazon. By the way, if you are making swimwear, I have found that nylon/spandex fabrics fade very quickly. Polyester/Spandex blends with 4-way stretch are far superior as far as overall wear and fade resistance than nylon/Spandex blends for swimwear. Just in case you planned on swimwear and don't want to waste your time and effort on something that will fade quickly. As for thread, I use Coats and Clark Dual Duty thread. Unfortunately, the variety of Polyester/Spandex blends is not as big as the nylon/Spandex fabrics. I know you addressed your question to Jim, but I thought I would jump in and give my take on the subject also. Happy stitching! Kathy S, Camas WA