I work with Multipsk under Win 10 Pro 64-bit without any problems. Like some others.
Did you try to run it as administrator? Not only the installation.
- Kill all background running tasks of Multipsk or make a reboot.
- Right-click the program and go to Properties –> Shortcut.
- Go to Advanced.
- Check Run as Administrator checkbox. Run as administrator option for program.
Maybe this helps to get Multipsk run on your pc's.