Thanks again, I changed true to false and gave it a shot, Sadly no difference.
More on the issue: (no front ends running)
1, When expanding and collapsing plugins on the left pane there will be miss clicks. e.g click to collapse nothing happens click again and it collapses but sometimes can take 3 clicks to work and vica versa.
2, Moving the mouse cursor around with SDR# open (no with or without a Front end active) randomly results in a 1 sec mouse freeze then it unfreezes inside SDR# and throughout the whole OS environment like now compiling this reply.
Only does this with SDR# version 1.5 and above and I've even tried a fresh OS install on a spare SSD to see if my main environment was bugged somehow.
Annunaki/Zenocide from IRC years ago.