SPORTS MEDICINE : MEDICAL: CONDITIONS: OBESITY : MEDICAL: DISEASES: DIABETES : MEDICAL: TREATMENTS: Exercise Mimic Molecule May Help Treat Diabetes and Obesity

David P. Dillard
 

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SPORTS MEDICINE :

MEDICAL: CONDITIONS: OBESITY :

MEDICAL: DISEASES: DIABETES :

MEDICAL: TREATMENTS:

Exercise Mimic Molecule May Help Treat Diabetes and Obesity

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Exercise Mimic Molecule May Help Treat Diabetes and Obesity

Date:

July 27, 2015

Source:

University of Southampton

Summary:

Scientists have developed a molecule that acts as an exercise mimic, which could potentially help treat type 2 diabetes and obesity. The new molecule, called 'compound 14', inhibits the function of a cellular enzyme called ATIC, which is involved in metabolism, leading to the build-up of a molecule called ZMP in cells. This increase in ZMP makes cells think that they have run out of energy by activating the cell's central energy sensor, known as AMPK, thereby causing cells to try and increase their energy levels by increasing glucose uptake and metabolis

Science Daily

http://www.sciencedaily.com/releases/2015/07/150727092803.htm

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Scientists from the University of Southampton have developed a molecule that acts as an exercise mimic, which could potentially help treat type 2 diabetes and obesity.

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The new molecule, called 'compound 14', inhibits the function of a cellular enzyme called ATIC, which is involved in metabolism, leading to the build-up of a molecule called ZMP in cells. This increase in ZMP makes cells think that they have run out of energy by activating the cell's central energy sensor, known as AMPK, thereby causing cells to try and increase their energy levels by increasing glucose uptake and metabolism.

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Publishing in the journal Chemistry and Biology, the researchers found that activating AMPK with compound 14 led to a reduction in fasting blood glucose levels, improved glucose tolerance and, at the same time, promoted weight loss in obese mice.

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Dr Ali Tavassoli, Professor of Chemical Biology at the University of Southampton whose research team discovered and developed compound 14, says: "There is a lot of evidence from previous studies that if you could selectively activate AMPK with a small molecule, it could have potential benefits in the treatment of several diseases, including type 2 diabetes, by acting as an exercise mimetic and increasing the uptake and usage of glucose and oxygen by cells. Our molecule, which activates AMPK by altering cellular metabolism, therefore holds much promise as a potential therapeutic agent."

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The complete article may be read at the URL above.

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Journal Reference:


Daniel J. Asby, Francesco Cuda, Maxime Beyaert, Franchesca D. Houghton, Felino R. Cagampang, Ali Tavassoli. AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization. Chemistry & Biology, 2015; 22 (7): 838 DOI: 10.1016/j.chembiol.2015.06.008

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Cite This Page:

University of Southampton. "Exercise mimic molecule may help treat diabetes and obesity." ScienceDaily. ScienceDaily, 27 July 2015. <www.sciencedaily.com/releases/2015/07/150727092803.htm>.


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