SPORTS MEDICINE : MEDICAL: CONDITIONS: OBESITY : MEDICAL: DISEASES: DIABETES : MEDICAL: TREATMENTS: Exercise-Mimicking Molecule May Offer New Treatments for Obesity, Type 2 Diabetes

David P. Dillard
 

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SPORTS MEDICINE :

MEDICAL: CONDITIONS: OBESITY :

MEDICAL: TREATMENTS :

MEDICAL: DISEASES: DIABETES :

Exercise-Mimicking Molecule
May Offer New Treatments for Obesity, Type 2 Diabetes

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Exercise-Mimicking Molecule
May Offer New Treatments for Obesity, Type 2 Diabetes

Published: Tuesday 28 July 2015 at 8am PST

Honor Whiteman

Medical News Today (MNT)

http://www.medicalnewstoday.com/articles/297363.php

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Researchers from the UK have developed a molecule that mimics exercise - a creation they say could lead to treatments for obesity and type 2 diabetes.

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The new molecule - called "compound 14" - was developed by Ali Tavassoli, professor of chemical biology at the UK's University of Southampton, and his research team.

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Compound 14 works by blocking the function of a cellular enzyme called ATIC, which plays an important role in metabolism.

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Blocking ATIC function leads to accumulation of a molecule called ZMP in cells, which activates cells' central energy sensor - called AMPK - causing them to think they are low in energy. As such, the cells attempt to boost energy levels by increasing metabolism and uptake of glucose.

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For their study, Tavassoli and colleagues tested compound 14 on two groups of mice. One group was fed a normal diet while the other was fed a high-fat diet, making them obese and glucose intolerant - a sign of prediabetes.

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Their findings were recently published in the journal Chemistry & Biology.

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The team found that mice treated with compound 14 who were fed a normal diet retained a normal weight and blood glucose levels.

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However, mice fed a high-fat diet who were treated with a single dose of the compound demonstrated a reduction in blood glucose levels, bringing them to near-normal.

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In addition, when the mice fed a high-fat diet were given a single dose of compound 14 daily for 7 days, their glucose tolerance improved and they shed approximately 5% of their body weight.

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The complete article may be read at the URL above.

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