MEDICAL: CONDITIONS: OBESITY : MEDICAL: DISEASES: CANCER : RELATIONSHIPS AND LINKS: Overweight / Obesity Linked to Eight More Cancers

David P. Dillard
 

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MEDICAL: CONDITIONS: OBESITY :

MEDICAL: DISEASES: CANCER :

RELATIONSHIPS AND LINKS:

Overweight/Obesity Linked to Eight More Cancers

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Overweight/Obesity Linked to Eight More Cancers

Zosia Chustecka

August 25, 2016

Medscape

http://www.medscape.com/viewarticle/867919

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Being overweight/obese is already known to increase the risk for certain cancers, but this association has just become much wider. Another eight cancers have been added to the list, joining the five already there.

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The new findings come from the International Agency for Research on Cancer (IARC), which is part of the World Health Organization (WHO). They are published in the IARC Handbooks of Cancer Prevention, Volume 16: Body Fatness, which provides an update of part of IARC Handbooks of Cancer Prevention Volume 6: Weight Control and Physical Activity, published in 2002.

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A summary was published online August 25 in the New England Journal of Medicine.

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Rather than saying that overweight/obesity increases the risk for cancer, the IARC has presented its findings another way: "the absence of excess body fatness reduces the risk of cancers."

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The IARC confirmed its previous findings (published in 2002) for five cancers ? colorectal, esophageal (adenocarcinoma), renal cell carcinoma, breast cancer in postmenopausal women, and uterine endometrial cancer.

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Now, from a new evaluation of published scientific literature, the agency has added eight more cancers to that list: stomach (gastric cardia), liver, gall bladder, pancreas, ovarian, thyroid, meningioma, and multiple myeloma.

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There is also limited evidence suggesting a link for three other cancers ? fatal cancer of the prostate, breast cancer in men, and diffuse large B-cell lymphoma.

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Several mechanisms linking excess body fat with carcinogenesis were identified, including chronic inflammation and dysregulation of the metabolism of sex hormones, the IARC notes.


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The complete article may be read at the URL above.

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Overweight, Obesity, and Mortality in a Large Prospective
Cohort of Persons 50 to 71 Years Old

Kenneth F. Adams, Ph.D., Arthur Schatzkin, M.D., Tamara B. Harris, M.D., Victor Kipnis, Ph.D., Traci Mouw, M.P.H., Rachel Ballard-Barbash, M.D., Albert Hollenbeck, Ph.D., and Michael F. Leitzmann, M.D.

August 24, 2006 vol. 355 no. 8

http://www.nejm.org/doi/pdf/10.1056/NEJMoa055643


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