Recent update to latest Flex 6500 software SmartSDR v2.8.1 and radio works normally.  DXLab Commander will not connect to Flex 6500 new software although DXLabSuite worked perfectly with prior v2.8.0.  The new Flex software is required following a recent Windows 10 update.
Any help appreciated...thanks, in advance.
Mike, K6DRY, email:  mhreid4@...

+ AA6YQ comments below

Recent update to latest Flex 6500 software SmartSDR v2.8.1 and radio works normally. DXLab Commander will not connect to Flex 6500 new software although DXLabSuite worked perfectly with prior v2.8.0. The new Flex software is required following a recent Windows 10 update.

+ There's been no indication from Flex that it made changes in SmartSDR 2.8.1 that would prevent it from working with Commander. I suggest that you engage with Flex support; if my assistance is required, they know how to contact me.

73,

Dave, AA6YQ

Guessing here that your com ports have gotten switched.  
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73!
David, N4IW

I updated my Flex 6600M to 2.81 yesterday.  DXLabs works fine with it, no issues, no config changes needed.  If you use SmartSDR CAT and DAX did they get restarted on your pc after the upgrade? Or if you use IP interface in Commander did the radio IP address change?

Wray AB4SF