I have used my Raspberry Pi 4 to run the WSJT-X with the uBITX, so it is possible. I will go back an dig up the details. One thing I do remember is that you still need a separate dongle for it to work. that is the same one I used for the Windows version.
It may take a couple of days to recreate what I did, as I have dismantled my Pi station (Using a Windows 10 laptop now).